Journal: Clinical Science

Authors: Antoneta Granic, Karen Suetterlin, Tea Shavlakadze, Miranda D. Grounds, Avan Aihie Sayer

Summary: This review examines how the nine classic hallmarks of ageing, including mitochondrial dysfunction and cellular senescence, contribute to sarcopenia, the age-related decline in skeletal muscle mass and function. We further highlight five novel hallmarks specific to skeletal muscle ageing: inflammation, neural dysfunction, extracellular matrix dysfunction, reduced vascular perfusion, and ionic dyshomeostasis.These hallmarks are interconnected and may significantly influence sarcopenia development. However, there is limited research involving older women, which is needed to understand the complex interplay of these hallmarks and their clinical implications for developing effective interventions to mitigate sarcopenia and improve quality of life in the ageing population.

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