In our liver disease theme, we explore the contribution that the ageing process makes to the biology of liver disease. To do this, we harness the expertise of Newcastle’s world-class ageing biology research.
Theme co-leads are; Quentin Anstee, Professor of Experimental Hepatology and an Honorary Consultant Hepatologist at Newcastle Hospitals. He leads one of the largest MASLD clinical services in the UK.
And Helen Reeves, Professor of Liver Cancer and an Honorary Consultant Hepatologist at Newcastle Hospitals. She leads care for patients with liver disease and cancer in the UK.
What we cover in this theme
Newcastle BRC’s Liver Disease Theme studies the following conditions:
We are researching the mechanisms behind these conditions in order to find treatments that can improve the quality life and survival of those affected.
Journal: Gut. 2022 2022: 71(10):2093–106. doi.org/10.1136/gutjnl-2021-326259
Authors: Leslie J, Mackey JBG, Jamieson T, Ramon-Gil E, Drake TM, Fercoq F, Clark W, Gilroy K, Hedley A, Nixon C, Luli S, Laszczewska M, Pinyol R, Esteban-Fabró R, Willoughby CE, Haber PK, Andreu-Oller C, Rahbari M, Fan C, Pfister D, Raman S, Wilson N, Müller M, Collins A, Geh D, Fuller A, McDonald D, Hulme G, Filby A, Cortes-Lavaud X, Mohamed NE, Ford CA, Raffo Iraolagoitia XL, McFarlane AJ, McCain MV, Ridgway RA, Roberts EW, Barry ST, Graham GJ, Heikenwälder M, Reeves HL, Llovet JM, Carlin LM, Bird TG, Sansom OJ, Mann DA.
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Journal: NNature Metabolism. 2023 Apr;5(4):572-578. doi.org/10.1038/s42255-023-00775-1Authors: ovaere O, Hasoon M, Alexander L, Cockell S, Tiniakos D, Ekstedt M, Schattenberg JM, Boursier J, Bugianesi E, Ratziu V; LITMUS Investigators; Daly AK, Anstee QM
Journal: Nature. 2025 Mar;639(8055):754-764. doi.org/10.1038/s41586-025-08585-z
Authors: Müller M, May S, Hall H, Kendall TJ, McGarry L, Blukacz L, Nuciforo S, Georgakopoulou A, Jamieson T, Phinichkusolchit N, Dhayade S, Suzuki T, Huguet-Pradell J, Powley IR, Officer-Jones L, Pennie RL, Esteban-Fabró R, Gris-Oliver A, Pinyol R, Skalka GL, Leslie J, Hoare M, Sprangers J, Malviya G, Mackintosh A, Johnson E, McCain M, Halpin J, Kiourtis C, Nixon C, Clark G, Clark W, Shaw R, Hedley A, Drake TM, Tan EH, Neilson M, Murphy DJ, Lewis DY, Reeves HL, Le Quesne J, Mann DA, Carlin LM, Blyth K, Llovet JM, Heim MH, Sansom OJ, Miller CJ, Bird TG
Journal: Lancet Gastroenterol Hepatol. 2025 Oct;10(10):924-940. doi.org/10.1016/s2468-1253(25)00128-1
Authors: Wong VW, Amin NB, Takahashi H, Darekar A, Tacke F, Kiszko J, Rodriguez H, Nakajima A, Alkhouri N, Charlton M, Anstee QM
Journal: J Hepatol. 2026 in press, accepted for publication, April 2026.
Authors: Lombardi P*, Ramon-Gil*, Raja R, Brunett L, Manfredi GF, Zhou Z, Merces G, Cappuyns S, Fulgenzi CAM, D’Alessio A, Torkpour A, Celsa C, Stefanini B, Yang H, Crowley F, Marron TU, Saeed A, Pinter M, Scheiner B, Huang YH, Lee PC, Nishida N, Po-Ting Lin R, Dalbeni A, Vivaldi C, Masi G, Rohlen N, von Felden J, Kaseb A, Galle PR, Kudo M, Hsu WF, Rimassa L, Parisi A, Kelley RK, Toyoda H, Pirisi M, Jabar RF, Rakaee M, Cabibbo G, Cammà C, Piscaglia F, Hwang S, Shin DJ, Li M, Dekervel J, Guerra N, Meyer T, Reeves HL, Bengsch B, Daniele G, Mann DA, Chon HJ, Leslie, Pinato DJ
LIVErNORTH: The Charity for Liver Patients
Theme Co-Lead for Liver Disease, Multimorbidity and Lifestyle
BRC Theme Leadership Track for Liver Disease, Multimorbidityand Lifestyle, Consultant Hepatologist & Head of Department for Liver Medicine at the Newcastle Liver Unit
BRC Theme Leadership Track for Liver Disease, Multimorbidity and Lifestyle, NIHR Academic Clinical Fellow in Gastroenterology and Hepatology