BRC Leadership Track for Liver Disease, Multimorbidity & Lifestyle
As a Lecturer in Cancer Immunology at Newcastle University, my research focuses on understanding how chronic liver disease shapes the immune environment and influences responses to therapy, particularly in liver cancer. By integrating multiplexed imaging, spatial transcriptomics, and functional assays on human tissue samples, our work seeks to define how immune dysregulation, metabolic stress, and fibrotic signalling converge to drive disease progression and therapy resistance. We use complementary laboratory models—including human liver tumour slice cultures—to explore potential interventions that could be translated into future therapies. Our ultimate aim is to generate mechanistic insights that inform more effective, personalised treatments for patients living with liver disease and its complications.