In our liver disease theme, we explore the contribution that the ageing process makes to the biology of liver disease. To do this, we harness the expertise of Newcastle’s world-class ageing biology research.
Theme co-leads are; Quentin Anstee, Professor of Experimental Hepatology and an Honorary Consultant Hepatologist at Newcastle Hospitals. He leads one of the largest MASLD clinical services in the UK.
And Helen Reeves, Professor of Liver Cancer and an Honorary Consultant Hepatologist at Newcastle Hospitals. She leads care for patients with liver disease and cancer in the UK.
What we cover in this theme
Newcastle BRC’s Liver Disease Theme studies the following conditions:
We are researching the mechanisms behind these conditions in order to find treatments that can improve the quality life and survival of those affected.
Journal: N Engl J Med. 2024 Jul 25;391(4):311-319. doi: 10.1056/NEJMoa2401755. Epub 2024 Jun 7. PMID: 38847460
Authors: Sanyal AJ, Bedossa P, Fraessdorf M, Neff GW, Lawitz E, Bugianesi E, An-stee QM, Hussain SA, Newsome PN, Ratziu V, Hosseini-Tabatabaei A, Schattenberg JM, Noureddin M, Alkhouri N, Younes R, 1404-0043 Trial Investigators
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Journal: Nat Cell Biol 26, 2075–2083 (2024). doi.org/10.1038/s41556-024-01543-3Authors: Kiourtis C, Terradas-Terradas M, Gee LM, May S, Georgakopoulou A, Col-lins AL, O'Sullivan ED, Baird DP, Hassan M, Shaw R, Tan EH, Müller M, Engelmann C, Andreola F, Hsieh YC, Reed LH, Borthwick LA, Nixon C, Clark W, Hanson PS, Sumpton D, Mackay G, Suzuki T, Najumudeen AK, Inman GJ, Campbell A, Barry ST, Quaglia A, Morris CM, LeBeau FEN, Sansom OJ, Kirschner K, Jalan R, Oakley F, Bird TG
Journal: In press. Journal of Hepatology 17/12/2024
Authors: Cappuyns S, Piqué-Gili M, Esteban-Fabró R, Philips G, Balaseviciute U, Pinyol R, Gris-Olive A, Vandecaveye V, Abril-Fornaguera J, Montironi C, Bassaganyas L, Peix J, Zeitlhoefler M, Mesropian A, Huguet-Pradell J, Haber PK, Figueiredo I, Ioannou G, Gonzalez-Kozlova E, D’Alessio E, Mohr R, Meyer T, Lachenmayer A, Marquardt JU, Reeves HL, Edeline J, Finkelmeier F, Trojan J, Galle PR, Foerster F, Mínguez B, Montal R, Gnjatic S, Pinato DJ, Heikenwalder M, Verslype C, Van Cutsem E, Lam-brechts D, Villanueva A, Dekervel J, M. Llovet JM
Journal: Nature 2025. In press
Authors: Müller M, May S, Hall H, Kendall T, McGarry L, Blukacz L, Nuciforo S, Ja-mieson T, Phinichkusolchit N, Dhayade S, Leslie J, Sprangers J, Malviya G, Mrowinska A, Johnson E, McCain M, Halpin J, Kiourtis C, Geor-gakopoulou A, Nixon C, Clark W, Shaw R, Hedley A, Drake T, Hong Tan E, Neilson M, Murphy D, Lewis D, Reeves H, Mann D, Blyth K, Heim M, Car-lin L, Sansom O, Miller C, Suzuki T, Huguet-Pradell J, Powley I, Officer-Jones L, Pennie R, Esteban-Fabró R, Gris Oliver A, Pinyol R, Skalka G, Hoare M, Clark G, Le Quesne J, Llovet J, Bird T
Journal: BMJ Open. 2024 Jun 12;14(6):e082155. doi: 10.1136/bmjopen-2023-082155. PMID: 38866571
Authors: Hallsworth K, McCain MV, Fallen-Bailey R, Brown MC, Orange ST, Reeves HL
THRIVE is an EU-funded initiative that brings together a strong and multidisciplinary team with 13 partners, from 8 countries, with complementary expertise in liver cancer research and in the use of cutting-edge technologies
Prof. Helen Reeves is leading the evaluation of clinical/molecular features to identify determinant of liver cancer onset and progression (WP2)
Supported by the Liver Theme, Dr Kate Hallsworth has secured an NIHR Senior Clinical and Practitioner Research Award – 5 year personal fellowship (NIHR304350). She has also received a NuTH Celebrating Excellence Award for the Active Hospitals Team in the Innovation, Transformation and Research category. She is an integral part of our AHP team, supporting ongoing clinical trials in our region, including ‘How can we improve the detection and management of metabolic dysfunction-associated steatotic liver disease in primary care settings? A qualitative interview study with healthcare professionals’ (running in Teesside). She has led the development and implementation of an innovative AHP-led group education programme for patients with metabolic dysfunction-associated steatotic liver disease at NuTH and she has been invited to be part of the European Association for Study of The Liver (EASL) Nurse and AHP Taskforce (3y tenure).
LIVErNORTH: The Charity for Liver Patients
Theme Co-Lead for Liver Disease, Multimorbidity and Lifestyle
BRC Theme Leadership Track for Liver Disease, Multimorbidityand Lifestyle, Consultant Hepatologist & Head of Department for Liver Medicine at the Newcastle Liver Unit
BRC Theme Leadership Track for Liver Disease, Multimorbidity and Lifestyle, NIHR Academic Clinical Fellow in Gastroenterology and Hepatology